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Your Guide to Revolutionary Cognitive Enhancement

lostfalco@gmail.com
Lostfalco.comLostfalco.com
Lostfalco.comLostfalco.com

Hi, I'm Lostfalco,
Foolish Self-Experimenter Extraordinaire
My experiments will show you how to build the brain,
and life, you've always wanted.
Let's see what works!

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A little one-two punch to the head…

Home UncategorizedA little one-two punch to the head…

A little one-two punch to the head…

April 18, 2016 Posted by lostfalco@gmail.com 6 Comments

So, I’ve been testing out a simple neuroinflammation stack for the past couple of weeks and the results have been nothing less than profound.

As many of you know, it takes quite a bit to get added to my short list of substances (LLLT, intranasal insulin, galantamine, etc.) but a new powerhouse has earned its place among the greats.

What is this substance, you may ask?

Ibudilast.

I booty what!?!

Ibudilast is a prescription medication (for asthma) that has been available in Japan for over 20 years, easily crosses the blood brain barrier, and primarily works by inhibiting excessive microglia (the primary immune cells of the CNS) activation.

The Stack

As many of you will remember, I’ve talked extensively about THE MASTER REGULATOR of inflammation in the body: the cholinergic anti-inflammatory pathway.

My favorite activator of this pathway is galantamine which, combined with ibudilast, gives me an absurd amount of clear-headed focus for the entire day.

For you mathematicians out there: galantamine + ibudilast = holy crap I feel good.

How does it work?

Tune back in this Friday (Apr 22) and I will explain why there is such a profound synergy between these two substances.

In the meantime, check out this free full text article (if you don’t want to wait for my busy ass!) for a little hint into the mechanisms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/

I’ll see you guys back here in a few days!

Same Falco time, same Falco channel.

LF out. (mic drop)

God, I’m a dork. ha

Where to buy:

Ibudilast

Galantamine Powder

Galantamine Capsules

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About lostfalco@gmail.com

Over the past decade I've taken 500+ substances and performed thousands of self-experiments to improve my brain and my life. And now, I'm here to share with you the best of the best so that you can achieve life-changing results in a fraction of the time at fraction of the price. You won't find information like this anywhere else in the world! So, read on to discover how to attain the mind, and the life, you've always wanted.

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6 Comments

Leave your reply.
  • Nedbert
    · Reply

    December 24, 2017 at 3:13 AM

    Hello, LF. I have been a Longecity lurker for about a year now while trying to address some serious memory issues. My effort is somewhat two-ponged. On the cognition side, memory is of major concern – it used to be my best asset, but now I would say, subjectively, that I’m operating at about 40% of my former capability due to age and some medical issues. Whether I find a good solution is questionable, but I continue to search since it creating some seriously distressing functional problems in my life. I digress – I’m paying very close attention to your experiences, stumbled on to your one-two-punch article while researching PRL. I may try out INI as the experience you describe sounds to be a systemic and may be more relevant to my question below.

    As for the second prong. Mental stamina. The water is muddied a bit on this since I do believe there is a physical component at play with my body in regards to this, as well. :/ What are your thoughts on drugs such as Bromantane that are described to have a general effect on stamina? Any personal experience?

  • Mikey
    · Reply

    October 19, 2016 at 2:40 AM

    You mention using agomelatine in your (likely my favorite that I’ve seen) stack; any chance you could give a quick blip as to why? MoA, synergy with other items on the list and subjective experience would be great!

  • LongLife
    · Reply

    May 24, 2016 at 3:15 AM

    Isn’t this similar to MONTELUKAST, asthma medication found recently to be a relief for Alzheimer’s due to it’s anti-inflammatory properties?

    http://www.longecity.org/forum/topic/83185-montelukast-as-a-nootropic/
    Post #5 and forward.

    • lostfalco@gmail.com
      · Reply

      Author
      May 24, 2016 at 1:46 PM

      Hey LongLife, it’s similar in that montelukast targets inflammation/microglia. However, the mechanism by which montelukast works in the (rodent) brain is through inhibition of GPR17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639806/

      So, it’s similar but different. I’ve actually tried montelukast as well and the effects are certainly distinct from ibudilast. Personally, I like ibudilast better (so far) but I think montelukast is a very interesting substance worth keeping an eye on.

      • LongLife
        · Reply

        May 25, 2016 at 4:50 AM

        Okay, Lostfalco, thank you.

        When ordering ibudilast from the supplier you mention, how long does it take to receive it please; I assume they accept Pay Pal?

        Did you ever try PRL-8-53? For memory, any comments.

        • lostfalco@gmail.com
          · Reply

          Author
          May 25, 2016 at 6:17 AM

          You’re very welcome.

          It takes about 2 to 3 weeks for me in the U.S. I used a card. A prepaid debit card isn’t a bad idea.

          I’ve tried PRL 8-53 numerous times and I’ve never been able to make it work for me. There is very little known about its mechanism of action (just some speculations about acetylcholine, dopamine, etc.) so it’s hard to know what to stack it with.

          I do very well with LLLT, intranasal insulin, PDE5i, PDE4i, galantamine, MK-677, concentrated oxygen, agomelatine, etc. so I’m in pretty good shape without it.

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